We discover the regulation of chromatin structure in
cardiomyocyte differentiation, neurodevelopment, and cancer.
One Genome, Multiple Epigenomes (Cardiomyocyte beating and epigenetic regulation)
When cardiomyocytes differentiate from embryonic stem cells, these two different types of cells have an identical genotype but exhibit distinct phenotypes. This is due to the difference in gene expression and epigenetics is to study how cells regulate gene expression in a context-dependent manner.
We are currently investigating how heterochromatin is regulated during cardiomyocyte beating. Our goal is to understand how cells adapt to the new environment to protect cells from mechanical stress. This basic understanding will provide new therapeutic approaches to cure heart-related diseases.