HOW H3K27M ONCOHISTONE INHIBITS PRC2 IN DIPG?
(Lee*/Yu*/Granat* et al., G&D, 2019)
(Stafford*/Lee* et al., Science Advances, 2018)
These two papers describe how H3K27M (lysine-to methionine mutation at residue 27 on H3) inhibits the catalytic activity of PRC2.
We will investigate how the structure of PRC2 is altered by H3K27M in DIPG and screen for PRC2 activator that restore PRC2 activity.