HOW CELLS FIND THEIR IDENTITY?
One genome, Multiple phenotypes
POLYCOMB-MEDIATED GENE SILENCING
We are investigating spatiotemporal regulation of PRC2 activity in different cellular contexts. We are also elucidating the pathogenesis of PRC2-associated human diseases such as B-cell lymphoma, pediatric brain tumor, cardiomyocyte regeneration and so on.
MISREGULATION OF CHROMATIN REGULATORS IN RARE DISEASES
We are investigating the aberration of chromatin regulators in neurodevelopmental diseases and cancer, focusing on the mechanism-function-disease relationship.
MOLECULAR DYNAMICS OF INTRINSTICALLY DISORDERED REGIONS
Intrinsically Disordered Regions (IDRs) have the ability to react quickly in response to changes in their environment, and play diverse roles in the modulation and control of the functions of their binding partners. Therefore, we are developing a broad-based and systematic biochemical approach to isolate and investigate IDRs.