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Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and ~~

Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and noncoding mutations in congenital heart disease (published in Cell)

2022-12-22


  • Single-cell chromatin data dissect distinct TF cardiogenesis regulatory programs

  • Dynamic transcription factor activity defines major differentiation trajectories

  • Molecular benchmarking with in vivo cells enables the optimization of in vitro protocols

  • Neural networks prioritize non-coding de novo mutations in congenital heart disorders





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