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Molecular and spatial signatures of mouse brain aging at single-cell resolution (published in Cell)

Updated: Jan 2, 2023

William E. Allen, Timothy R. Blosser, Zuri A. Sullivan, Catherine Dulac, Xiaowei Zhuang

2022-12-28

  • Molecular and cellular architecture of aging frontal cortex and striatum is mapped

  • Aging induces spatially dependent cell-state changes in non-neuronal cells

  • White matter is a hotspot for aging-related glial and immune cell activation

  • Aging- and LPS-induced brain inflammation exhibit similarities and differences







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