Molecular and spatial signatures of mouse brain aging at single-cell resolution (published in Cell)

William E. Allen, Timothy R. Blosser, Zuri A. Sullivan, Catherine Dulac, Xiaowei Zhuang

2022-12-28

• Molecular and cellular architecture of aging frontal cortex and striatum is mapped

• Aging induces spatially dependent cell-state changes in non-neuronal cells

• White matter is a hotspot for aging-related glial and immune cell activation

• Aging- and LPS-induced brain inflammation exhibit similarities and differences

paper link : https://www.cell.com/cell/fulltext/S0092-8674(22)01523-9